DANAZOL

Indications & Dose:

Adults:BY MOUTH Dysfunctional uterine bleeding;, 200 mg daily for 3 months. Start on 1st day of menstrutation and continue without interruption Children : Not recommended • Fibrocystic breast disease: •  BY MOUTH Initially 300mg daily for 3-6 months • Mastalgia: •  BY MOUTH 100-400 mg daily for 6 months • Gynaecomastia: •  BY MOUTH 400 mg daily for 6 months Children, 200mg daily for 6 months, if no response after 2 months increase to 400mg daily. • Endometrriosis; •  BY MOUTH Start on 1st day of menstrutation and continue without interruption, 200-800mg daily for 6-9 months. Prior to ablation, 400-800mg daily for 3-6 weeks
Children: Not recommended.

Contraindications:

Side Effects:

CNS: Dizziness, emotional lability, fatigue, headache, nervousness, sleep disorders, tremor
CV: Elevated blood pressure
GI: Constipation, hepatic dysfunction (doses >400 mg/day), nausea, vomiting, pancreatitis
GU: Clitoral hypertrophy, hematuria, pelvic pain, testicular atrophy, menstrual irregularities (spotting, amenorrhea; cycle disturbances), vaginal dryness METAB: Decreased HDL, increased LDL
SKIN: Acne, edema, flushing, mild hirsutism, oily skin or hair, sweating 
MISC: Changes in libido, decrease in breast size, deepening of the voice, glucose intolerance, weight gain 

Cautions:

Precautions:

Breast cancer, longterm use, epilepsy, migraine; cardiac, renal, or hepatic dysfunction 

Interaction:

Drugs
Carbamazepine: Predictably increases serum carbamazepine concentrations, toxicity possible
Cyclosporine: Increased serum cyclosporine concentrations, toxicity possible HMG-CoA reductase inhibitors (lovastatin, pravastatin): Myositisrisk increased Oral anticoagulants: Enhanced hypoprothrombinemic response Tacrolimus: Increased tacrolimus concentrations, toxicity possible 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: