Goserelin

Indications & Dose:

Advanced prostate carcinoma, endometriosis, breast cancer, endometrial thinning agent for dysfunctional uterine bleeding

• BY INJECTION

Adult

• SC 3.6mg into upper abdominal wall 4 wk: recommended duration in endometriosis is 6 mo

• Prostate carcinoma: SC 10.8mg into upper abdominal wall q 12 wk

Contraindications:

Pregnancy

Side Effects:

Cautions:

Precautions:

Patients at risk for osteoporosis (alcoholism, tobacco abuse, family history, chronic anticonvulsant therapy, chronic corticosteroid use)

Interaction:

Labs

Increase: Alk phosphatase, estradiol, FSH, LH, testosterone levels (1st week)
Decrease: Testosterone levels (after 1st week), progesterone 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category X: excretion into breast milk unknown: use caution in nursing mothers 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anxiety, depression, emotional lability, headaches, insomnia, nervousness, spinal cord compression
CV: Cerebrovascular accident, chest pain, dysrhythmia, hot flashes, hypertension, MI
GI: Constipation, diarrhea, nausea, ulcer, vomiting
GU: Breakthrough bleeding, decreased libido, renal insufficiency, spotting, urinary obstruction, UTI, vaginal dryness
METAB: Gout, hyperglycemia MS: Decreased bone mineral density, osteoneuralgia
SKIN: Alopecia, dry skin, pain on inj, rash, skin discoloration, sweating
MISC: Breast tenderness, change in breast size, gynecomastia 

Patient And Carer Advice: