Sodium CloDronate

Indications & Dose:

Osteolytic lesions, hypercalcaemia and bone pain associated with skeletal metastasses in breast cancer or multiple myeloma. Hypercalcaemia of malignancy.

• BY MOUTH

Adults:

Cap. 4-8 Caps into to divided doses 2 hour before after meal

• BY INJECTION

300mg daily by 8/mg 1/2 infusion for upto 7 days. Maintenance use Capsules.

CHILDRENS: Not recommended.

ALSO: INJECTION 

INDICATIONS  Hypercalcaemia of malignancy.

DOSAGES

Adults: Initially 1500 mg asa single inf. over 4 hrs for up to 7 days. Maintanance use caps/tabs.

CHILDREN: Not recommended.  

Contraindications:

 pregnancy 

Side Effects:

GI upset, renal dysfunction. Transient proteinurea. Reversible levations of parathyroid hormone, creatinin, lactate dehydrogenase, transaminase, alkaline phosphatase. Rarely asymptomatic hypocalcaemia, skin reactions. 

Cautions:

Precautions:

Interaction:

Drugs

Other bisphosphonate, antacids, mineral supplements, NSAIDs. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Renal impairment, Maintain adequate fluid intake. 

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: