Dapagliflozin

Indications & Dose:

Type 2 diabetes mellitus as monotherapy (if metformin inappropriate) | Type 2 diabetes mellitus in combination with insulin or other antidiabetic drugs (if existing treatment fails to achieve adequate glycaemic control)
BY MOUTH Adult 18–74 years: 10 mg once daily Adult 75 years and over: Initiation not recommended DOSE ADJUSTMENTS DUE TO INTERACTIONS Dose of concomitant insulin or drugs that stimulate insulin secretion may need to be reduced. 

Contraindications:

 Ketoacidosis 

Side Effects:

Common or very common Back pain . constipation .dyslipidaemia . dysuria . genital infection . hypoglycaemia(in combination with insulin or sulphonylurea) . polyuria . sweating . thirst . urinarytract infection Uncommon Dehydration . dizziness . hypotension .hypovolaemia . nausea . nocturia . raised serum creatinine .raised serum urea . rash PREGNANCY Avoid—toxicity in animal studies. BREAST FEEDING Avoid—present in milk in animal studies. HEPATIC IMPAIRMENT Initial dose 5 mg daily in severe impairment, increased according to response. RENAL IMPAIRMENT Avoid if eGFR less than 60 mL/minute/1.73m2 (ineffective). 

Cautions:

Cardiovascular disease (risk of hypotension) . elderly (risk of hypotension) . electrolyte disturbances . hypotension . raised haematocrit CAUTIONS, FURTHER INFORMATION Volume depletion Correct hypovolaemia before starting treatment. 

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

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Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: