BECLOMETHASONE DIPROPIONATE (SYSTEMIC)

Indications & Dose:

Ulcerative colitis:

Prophylaxis of asthma, allergic minitis, treatment of allergic rhintis, oral ulceration, ulcerative colitis.

• BY MOUTH

Adults: 5mg in morning daily max duration 4 weeks. 

Contraindications:

Systemic fungal infections unless specific anti-infective therapy is used. Head injury, stroke. 

Side Effects:

Cautions:

Precautions:

Active infections not controlled by antibiotics. Latent or active amoebiasis. History of TB, septicaemia, symptoms may be masked. Avoid or maintain extreme cautions in chickenpox, measles, psychiatric disorders, renal impairment, hepatic failure, cirrhosis, active peptic ulcer, myasthenia gravis, previous steroid myopathy, osteoporosis, epilepsy, hypothyroidism, diabetes, adrenal suppression, hypertension, recent MI, congestive heart failure, thromboembolic disorders, glaucoma, corneal perforation.

WITHDRAWAL: Withdrawal gradually. Withdrawal symptoms may include fever, myalgia, arthralgia, rhinitis, itchy skin nodules and weight loss. 

Interaction:

Live vaccines or other vaccines, anticoagulants, hypoglycaemia agents, antihypertensives, diuretics, erythromycin, rifamycins, amphotericin, azole antifungals, ritonavir, ciclosporin, cardiac glycosides. Oestrogens including oral contraceptives, somatropin. Carbamazepine, phenytoin, primidone, barbiturates. Muscle relaxants, NSAIDs, salicylates, sympathomimetics, mifepristone, methotrexate, theophylline, aprepitant.

Warnings:

Adverse Effects:

Endocrine irregularities including menstrual problems, Cushingoid state, adrenal suppression, growth suppression in children. Increased susceptibility to infection, increased severity of infection. Fluid/electrolyte distubance, hypertension, negative protein, nitrogen and calcium balance. Myopathy, tendon rupture, osteoporosis, osteonecrosis and fractures. Impaired wound healing, sweating, hisutism, straie, telangiectasis, acne. GI disturbance, peptic ulceration, acute pancreatitis, candidasis. Psychiatric effects, neurological effects, insomnia. Diabetes, impaired glucose tolerance, weight gain, increased appetite. Ocular disturbances including cataracts, raised intraocular pressure, optic nerve damage, corneal changes, glaucoma. Thromboembolism, leucocytosis. 

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: