Demopressin

Indications & Dose:

• BY MOUTH:

Diabetes insipidus,

Adult and Child: initially 300 micrograms daily (in 3 divided doses); maintenance, 300-600 micrograms daily in 3 divided doses; range 0.21.2mg daily.

Primary nocturnal enuresis (with normal urine concentrating ability),

Adult: (under 65 years) and

Child: over 5 years (preferably over 7 years) 200 micrograms at bedtime, only increased to 400 micrograms if lower doses not effective (important: see also Cautions); withdraw for at least 1 week for reassessment after 3 months.

Postoperative polyuria/polydipsia,

adjust dose according to urine osmolality Intranasally

Diabetes insipidus, diagnosis,

Adult and child: 20mcg. Diabetes insipidus treatment – Adult 10-40mcg daily (in 1 or 2 divided doses)

Child : 5-20mcg. Infants may require lower doses.

Primary nocturnal enuresis (with normal urine concentrating ability),

Adult: (under 65 years) and \ Child over 5 years (preferably over 7 years) initially 20 micrograms at bedtime, only increased to 40 micrograms if lower dose not effective (important: see also Cautions); withdraw for at least 1 week for reassessment after 3 months

Nocturia associated with multiple sclerosis (when other treatments have failed),

Adult: (under 65 years) 10-20 micrograms at bedtime dose not to be repeated within 24 hours

Renal function testing (empty bladder at time of administration and limit fluid intake to 500mL from 1 hour before until 8 hours after administration),

Adult

40 micrograms;

Child: 1-15 years 20 micrograms, under 1 year 10 micrograms (restrict fluid intake to 50% at next 2 feeds to avoid fluid overload)

l BY INJECTIONS

Diabetes insipidus, diagnosis (subcutaneous or intramuscular).

Adult and Child: 2 micrograms (limit fluid intake to 500 mL from 1 hour before to 8 hours after administration)

Diabetes insipidus, treatment (subcutaneous, intramuscular or intravenous),

Adult: 1-4 micrograms daily;

Child: 400 micrograms

Renal function testing (empty bladder at time of administration and limit fluid intake to 500mL from 1 hour before until 8 hours after administration) (subcutaneous or intramuscular),

Adult and Child: 2 micrograms 

Contraindications:

 Type II B von Willebrand’s disease.

PREGNANCY, BREAST-FEEDING & OLD AGE:

Contraindicated. 

Side Effects:

CNS: Drowsiness, flushing, headache, lethargy, seizures
CV: Increased blood pressure
EENT: Congestion, nasal irritation rhinitis
GI: Cramps, heartburn, nausea
GU: Vulvar pain 

Cautions:

Precautions:

Coronary artery disease, hypertensive cardiovascular disease, elderly, children: for bleeding disorders, proven safe and effective for age >3 months (parenteral) or >11 months (Stimate intranasal). 

Interaction:

Drugs
Analgesics: Effect of desmopressin potentiated by indomethacin

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: