ENTECAVIR

Indications & Dose:

Chronic hepatitis B infection with com-and pensated liver disease, evidence of viral replication, and histologically documented active liver inflame-mation or fibrosis .

• BY MOUTH

Adult

Over 18 years, not previously treated with nucleoside analogues, 500 micrograms once daily

Adult

Over 18 years with lamivudine-resistant chronic hepatitis B, 1 mg once daily

Counselling

To be taken at least 2 hours before or 2 hours after food 

Contraindications:

breast-feeding 

Side Effects:

nausea, vomiting dyspepsia, diarrhea, raised serum amylase and lipase; headache, fatigue. Dizziness, sleep disturbances; less commonly throm-bocytopenia 

Cautions:

Monitor liver function tests, and viral and serological markers for hepatitis B every 3 months; discontinue if deterioration in liver function repatic steatosis, progressive hepatomegaly or unexplained lactic acidosis; recurrent hepatitis may occur on dis-pregnancy 

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: