SULPHADOXINE+PYRIMETHAMINE

Indications & Dose:

Plasmodium falciparum malaria

• BY MOUTH

Adults

Prophylaxis, over 14 years, 1 weekly. Treatment, over 14 years, 2-3 tablet as a single dose.

Children

Prophylaxsis, under 4 years, quarter adult dose; 48 years, half adult dose; 9-14 years, 1/2 tab; 4-8 years, 1 tab; 9-14 years, 2 tabs. All as a single dose;

Syp: CURATIVE DOSE

Adults

15ml in single dose.

Children

Curative single dose: Under 4 years, 2.5ml, 4-6 years, 5ml; 7-9 years, 7.5ml; 10-14 years, 10ml. Prophylactic dose:

Adults

Non-immune subjects, 5ml as a single dose once in a week; semi-immune subjects, 10-15ml once every four weeks.

Children

Prophylactic dose: Under 4 years, 2.5ml as a single dose; 4-8 years, 5ml as a single dose; 9-14 years, 7.5ml as a single dose. The mentioned prophylactic dose is once every two weeks for nonimmune subjects while once every four weeks for semiimmune subjects. 

Contraindications:

Sulphonamide sensitivity, severe liver or kidney dysfunction. Blood dyscrasias. Neonates, pregnancy, lactation

Side Effects:

Cautions:

Precautions:

Interaction:

Drugs Folate inhibitors 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Perform regular blood counts, during long term prophylaxis. Avoid excess sun. 

Counselling:

Side Effects Or Adverse Reactions:

Skin rash, pharyngitis or pruritus (discontinue immediatly), G.I Distress, blood dyscrasias,. Rarely erythema multiforme. Stevens.Johnson syndrome. Lyell’s syndrome 

Patient And Carer Advice: