SULFADOXINE

Indications & Dose:

Prevention and treatment of plasmodium falciparum malaria.

• BY MOUTH

Adults

Prophylaxis. Over 14 years 50mg weekly treatment: over 14 years 500mg-1000mg  as a single dose.

Children

Prophylaxis: under 4 years quarter adult dose, 4-8 years half adult dose, 9-14 years three quarters of adult dose treatment, under 4 years 250mg 4-8years 500mg, 9-14 years 1000mg all as single doses. 

Contraindications:

 Sulphonamide sensitivity, severe liver & kidney dysfunction, blood dyscrasias, neonates, pregnancy, lactation

Side Effects:

Skin rash, pharyngitis or  pruritis, G.I. distress, blood dyscrasias, erythema multiform, Steven Johnson syndrome, Lyell’s syndrome.

Cautions:

Perform regular blood counte  during long term prophylaxis. Avoid excess sun. 

Precautions:

Interaction:

Folate inhibitors (phenytion, pyrimethamine) 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: