Clinical Pharmacology Details


NICLOSAMIDE


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Indications & Dose:

To treat bee/(Taenia saginata), fish (Diphyllobothrium latum), or pork (Taenia solium) tapeworm infestations



CHEWABLE TABLETS


Adults. 2 g as a single dose; repeated in 7 days, if needed.


Maximum: 2 g daily.


Children weighing more than 34 kg (75 Ib). 1.5 g as a single dose; repeated in 7 days, if needed.


Maximum: 2 g daily.


Children weighing 11 (24 Ib) to 34 kg. 1 g


as a single dose; repeated in 7 days, if needed.


Maximum: 2 g daily.


>• To treat dwarf tapeworm (Hymenolepsis nana) infestations


CHEWABLE TABLETS


Adults. 2 g daily for 7 days; repeated in 7 to 14 days, if needed.


Children weighing more than 34 kg. 1.5 g


on day 1 and then 1 g daily for next 6 days; repeated in 7 to 14 days, if needed.


Maximum: 2 g daily.


Children weighing 11 to 34 kg. 1 g on day


1 and then 500 mg daily for the next 6 days; repeated in 7 to 14 days, if needed.


Maximum: 2 g daily. 

Contraindications:

Side Effects:

Drowsiness, dizziness, headache, nausea, vomiting loss of appetite, diarrhea rash,pruritus ani, oral irritation, fever  rectal bleeding, weakness, bad taste in mouth, diaphoresis, palpitations, constipation, alopecia, edema in the arm, backache

Cautions:

Pregnancy, Breast-feeding: Use with caution.
Old age: May be used. 

Precautions:

Affects cestodes of the intestine only; it is without effect in cysticercoses .

Interaction:

ACTIVITIES


alcohol use: Decreased niclosamide effects 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Dizziness, drowsiness, headache, lightheadedness
EENT: Taste perversion
GI: Abdominal distress, anorexia, constipation, diarrhea, nausea, vomiting
SKIN: Anal pruritus, rash 

Patient And Carer Advice: