GRISEOFULVIN

Indications & Dose:

Fungal infections of the skin, hair, and nails (i.e., tines corporis, tines pedis, tines cruris, tinea barbae, tinea capitis, and tinea unguium) caused by susceptible organisms

DOSE

• BY MOUTH

Adult

• PO (microsize) 500-1000 mg/day in single or divided doses; (ultramicrosize) 330-375 mg/day in single or divided doses, max 750 mg/ day after meals but not less than 10mg/kg daily 

• BY MOUTH

Child >2 yr

• PO (microsize) 10-15 mg/kg/day in single or divided doses; (ultramicrosize) 5.5-7.3 mg/kg/day in single or divided doses with meals

Duration

• Tinea corporis: 2-4 wk

• Tinea capitis: At least 4-6 wk

• Tinea pedis: 4-8 wk

• Tinea unguium: 3-6 mo

Contraindications:

Porphyria, hepatocellular failure

Side Effects:

Cautions:

Precautions:

 Penicillin allergy (possible cross-sensitivity), lupus erythematosus 

Interaction:

Drugs
Aspirin: Reduces plasma salicylate level
Cyclosporine: Reduces plasma cyclosporine level

Oral contraceptives: Menstrual irregularities, increased risk of pregnancy possible
Phenobarbital: Reduces plasma griseofulvin level
Tacrolimus: Reduces plasma tacrolimus level
Warfarin: Reduces anticoagulant response 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C; since the use of an antifungal is seldom essential during pregnancy, avoid use during this time; excretion into breast milk unknown; use caution in nursing mothers

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Dizziness, fatigue, headache, insomnia, mental confusion, paresthesias (chronic use)
GI: Diarrhea, epigastric distress, GI bleeding, hepatic toxicity, nausea, oral thrush, vomiting
GU: Menstrual irregularities, proteinuria
HEME: Granulocytopenia, leukopenia
SKIN: Angioneurotic edema, photosensitivity, rash, urticaria 

Patient And Carer Advice: