SPARFLOXACIN

Indications & Dose:

Community-acquired pneumonia, acute bacterial exacerbations of chronic bronchitis caused by susceptible organisms

DOSAGE

• BY MOUTH

Adult • PD 400 mg x 1, then 200 mg qd for 9 days; for CrCl < 50m1/min, 400 mg x 1, then 200 mg q48h for 9 days 

Contraindications:

History of photosensitivity reactions, known prolonged QTc interval, children < 18 yr 

Side Effects:

CNS: Anxiety, depression, dizziness, fatigue, headache, insomnia, seizures, somnolence

CV: QTc interval prolongation

EENT: Dizziness, visual disturbances

GI: Abdominal pain, anorexia, diarrhea, dry mouth, flatulence, heartburn, increased AST, ALT; nausea, pseudomembranous colitis, vomiting

GU: Vaginal moniliasis

SKIN: Photosensitivity, pruritus, rash 

Cautions:

Precautions:

Seizure disorder, dehydration, renal impairment, hepatic impairment 

Interaction:

Drugs
• Aluminium: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

• Antacids: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

•  Antipyrine: Inhibits metabolistil of antipyrine; increased plasma antipyrine level

• Calcium: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

• Diazepam: Inhibits metabolism of diazepam; increased plasma diazepam level

. • Didanosine: Markedly reduced absorption of sparfloxacin; take sparfloxacin 2 hr before didanosine

• Foscarnet: Coadministration increases seizure risk

• Iron: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

•Magnesium: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

• Metoprolol: Inhibits metabolism of metoprolol; increased plasma metoprolol level

• Phenytoin: Inhibits metabolism of phenytoin; increased plasma phenytoin level

• Propranolol: Inhibits metabolism of propranolol; increased plasma propranolol level

•Ropinirole: Inhibits metabolism of ropinirole; increased plasma ropinirole level

• Sodium bicarbonate: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

• Sucralfate: Reduced absorption of sparfloxacin; do not take within 4 hr of dose

•Warfarin: Inhibits metabolism of warfarin; increases hypoprothrombinemic response to warfarin

• Zinc: Reduced absorption of sparfloxacin; do not take within 4 hr of dose 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C; excretion into breast milk unknown; due to the potential for arthropathy and osteoehondrosis, use extreme caution in nursing mothers

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: