PEFLOXACIN

Indications & Dose:

Respiratory tract, urinary tract, skin and soft tissue, surgical, bone and joint, gynaecological infections. Sexually transmitted, gastrointestinal and severe systemic infections. Gonorrhoea, Septicaemia, osteomyelitis and meningitis. 

DOSE

• BY MOUTH

Adults

Tab: With normal liver function: 400mg twice daily. An initial loading dose of 800mg may be given in order to produce effective blood concen-trations more rapidly.

•  BY INFUSION

Gonorrhoea: 800mg single dose. Inj: Admin. by slow i.v. inj. at a dose of 400mg diluted in 100-250ml of 5 per cent isotonic glucose solution (over a period of 1 hour), twice daily.

Children: Not recommended.

Contraindications:

 Pregnancy, breastfeeding,  G6PD deficiencies. Hypersensitivity, children below 15 years.

Side Effects:

Nausea, epigastric distress, arthralgia, skin rash, photosensitivity reaction, insomnia, headache, myalgia and thrombocytopenia. 

Cautions:

Precautions:

Hepatic dysfunction, avoid exposure to sunlight during treatment.

Old age: May be used. 

Interaction:

Drugs

Antineoplastic drugs: Decrease serum levels of pefloxacin.

Caffeine: Enhanced efficacy of caffeine.

Oral anticoagulants: Enhanced efficacy of anticoagulants.

Cyclosporine: Nephrotoxicity increased by pefloxacin.

Theophylline: Increased plasma levels of theophylline resulting in toxicity.

NSAIDs: CNS excitation may occur.

Rifampicin: Decreases serum concentration of pefloxacin.

Chloramphenicol: Antagonizes effects of pefloxacin

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: