MOXIFLOXACIN

Indications & Dose:

Infections of the upper (sinusitis) and lower (bronchitis, community acquired pneumonia) respiratory tract and skin caused by susceptible organism; antibacterial spectrum usually includes; 

DOSAGE

•  BY MOUTH

Adult and Child > 18yr

• Bronchitis, acute bacterial exacerbation of chronic bronchitis: PO 400 mg qd for 5 days

• Pneumonia, community acquired: PO 400 mg qd for 10 days

• Sinusitis, acute bacterial: PO 400 mg qd for 10 days

• Skin and skin structure infections: 400 mg qd for 7 days

Contraindications:

Side Effects:

Cautions:

Precautions:

May prolong the QT interval, avoid in patients with known prolongation of the QT interval, hypokalemia, or patients receiving class Ia (e.g., quinidine, procainamide) or class III (e.g., amiodarone, sotalol) antiarrhythmic agents, or cisapride, erythromycin, antipsychotics, and tricyclic antidepressants; brodychardia; acute myocardial infarction; known or suspected CNS disorders (e.g., severe cerebral arteriosclerosis, epilepsy) or in the presence of other risk factors that may predispoe to seizures or lower the seizure threshold 

Interaction:

Drugs

Aluminium: Reduced absorption of moxifloxacin; do not take within 4 h of dose

Antacids: Reduced absorption of moxifloxacin; do not take within 4 hr of dose

Antipyrine: Inhibits metabolism of antipyrine; increased plasma antipyrine level

Calcium: Reduced absorption of moxifloxacin; do not take within 4 hr of dose

Diazepam: Inhibits metabolism of diazepam; increased plasma diazepam level

Didanostine: Markedly reduced absorption of moxifloxacin; take moxifloxacin 2 hr before didanosine

Foscarnet: Coadministration increase seizure risk

Iron: Reduced absorption of moxifloxacin; do not take within 4 hr of dose

Magnesium: Reduced absorption of moxifloxacin; do not take within 4 hr of dose

Metoprolol: Inhibits metabolism of metoprolol; increased plasma metoprolol level

Morphine: Reduced absorption of moxifloxacin; do not take within 2 hr of dose

Pentoxyfylline: Inhibits metabolism of phenytoin; increased plasma phenytoin level

Propranolol: Inhibits metabolism of propranolol; increased plasma ropinirole level

Sodium bicarbonate: Reduced absorption of moxifloxacin; do not take within 4 hr of dose

Sucralfate: Reduced absorption of moxifloxacin; do not take within 4 hr of dose

Warfarin: inhibits metabolism of warfarin; increases hypoprothrombinemic response to warfarin

Zinc: Reduced absorption of moxifloxacin; do not take within 4 hr of dose 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C: excreted into breast milk, safety not established; allow 48 h to elapse after last dose before resuming breast feeding 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anxiety, asthenia, confusion, dizziness (3%), depersonalization, headache (2%), incoordination, insomnia, somnolence, tremor, vertigo

CV: Edema, hypertension, hypotension, palpitation, tachycardia, vasodilatation

EENT: Taste perversion, tinnitus

GI: Abdominal pain (2%), diarrhea (6%), dyspepsia (1%), nausea (8%), vomiting 2%, abnormal liver function test (1%), increased amylase, pseudomembranous colitis

 GU: Moniliasis, vaginitis, increase in BUN, creatinine

HEME: Leukopenia, prothrombin time decrease, prothrombin time increase, thrombocythemia, thrombocytopenia

METAB: Hyperglycemia MS: Arthralgia, myalgia, tendon inflammation, tendon rupture

RESP: Asthma, cough, increased dyspnea

SKIN: Urticaria, rash, pruritus, sweating 

Patient And Carer Advice: