RIFAMPICIN +INH+PYRAZINAMIDE

Indications & Dose:

Tuberculosis.

DOSAGE:

Adults & Children: 1 tab/1 h kg body wt: daily one or two hour before a meal.

Contraindications:

RIFAMPICIN: Previous hypersensitivity to any Rifampicin

ISONIAZID: Patients with previous isoniazid associated hepatic injury or other severe adverse reactions with isoniazid

PYRAZINAMIDE: Liver disease 

Pregnancy: C (Risk cannot be ruled out

Side Effects:

Cautions:

Precautions:

RIFAMPICIN: Not recommended for intermittent therapy caution patients against intentional or accidental interruption of daily dosage regimen, since rare renal hypersensitivity reactions have been reported when therapy is resumed Urine, ‘faeces, saliva, sputum sweat and tears may be colored red orange

ISONIAZID: Patients with active chronic liver die case or severe renal dysfunction. Isoniazid crosses the placenntal barrier and passes into maternal breast milk, observe neonates. Breast led infants of isoniazid treated mothers for any evidence of adverse effects

PYRAZINAMIDE: Perform frequently liver function tests and blood uric acid determinations. History of gout or diabetes. Withdraw treatment if liver damage or hyperuricemia accompanied by acute gouty arthritis occurs. 

Interaction:

Warnings:

Adverse Effects:

RIFAMPICIN: Heartburn, epigastric distress anorexia, nausea, vomiting, diarrhoea, sore mouth Rash, pruritus, urticaria. Eosinophilia, thrombocytopenia Muscular weakness, pain in extremities Visual disturbances Hemoglobinuria. hematuria. Menstrual disturbances.

ISONIAZID: Peripheral neuropathy. Nausea, vomiting epigastric distress elevated SGOT. SGPT.SGOPT

PYRAZINAMIDE: Hepatitis which can be minimized by dosage adjustment. 

Lactations:

(Risk cannot be ruled out (Caution advised or effect Undetermined) 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: