PYRAZINAMIDE

Indications & Dose:

Active tuberculosis (as part of a 6 mo regimen consisting of isoniazid, rifampin, and pyrazinamide given for 2 mo, followed by isoniazid and rifampin for 4 mo); after treatment failure with other primary drugs in any form of active tuberculosis 

DOSE

Adults: 20-35mg/kg body-wt. single dose. Max. 3g daily.

Children: Same dose by wt. 

Contraindications:

Severe liver disease, acute gout 

Side Effects:

Cautions:

Precautions:

History of gout, renal and hepatic function impairment, alcoholism, elderly, HIV infection (may require longer courses of therapy), diabetes mellitus 

Interaction:

Drugs

Cyclosporine: Decreased concentrations cyclosporine

Tacrolimus: Decreased concentrations of tacrolimus

Warnings:

Adverse Effects:

Lactations:

Excreted into human milk 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Fever

GI: Anorexia, hepatotoxicity, nausea, vomiting

GU: Iaysuria, interstitial nephritis (rare)

HEME: Blood clotting abnormalities, increased serum iron concentration, porphyria, sideroblastic anemia, thrombocytopenia

METAB: Gout, hyperuricemia

MS: Arthralgia, myalgia

SKIN: Acne, photosensitivity, pruritus, rash, urticaria 

Patient And Carer Advice: