TINIDAZOLE

Indications & Dose:

Adults

Amoebic liver abscess:

2g as a single dose repeated for 3 days.

Amoebiasis:

600mg twice daily for 5-10 days or 2g single dose daily for 2-3 days.

Giardiasis:

150mg twice daily for 7 days or 2g single dose once daily.

Children

10-15mg/kg/day divide every 8 hour for 5-7 days or 50mg/kg single dose.

Contraindications:

Neurological disorder, blood dyscrasias.

PREGNANCY: Contra-indicated in 1st trimester of pregnancy. 

Side Effects:

Nausea, epigastric discomfort, metallic taste, furred tongue, neuropathy, skin rash, urticaria, angioedema, leucopenia, seizures on prolonged therapy. 

Cautions:

Breast-feeding: Use with caution.

Old age: May be used in reduced dose.

Precautions:

Interaction:

DRUGS

cholestyramine: Possibly decreased bioavail-ability of tinidazole

cimetidine, ketoconazole: Possibly delayed elimination and increased blood level of tinidazole

cyclosporine, tacrolimus: Possibly increased serum cyclosporine and tacrolimus levels disulfiram:

Possibly combined toxicity, resulting in confusion and psychosis fluorouracil: Possibly decreased fluorouracil clearance

lithium: Possibly increased serum lithium levels

oral anticoagulants: Possibly increased anticoagulant effect

oxytetracydine: Possibly diminished effect of tinidazole

phenobarbital, phenytoin, rifampin: Possibly increased metabolism and decreased blood level of tinidazole 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Ataxia, dizziness, coma, confusion, depression, drowsiness, fatigue, fever, head-ache, insomnia, malaise, peripheral neuropathy, seizures, vertigo, weakness

CV: Palpitations 

EENT: Dry mouth, excessive salivation, furry tongue, metallic or bitter taste, oral candidiasis, pharyngitis, stomatitis, tongue discoloration

GI: Abdominal cramps, anorexia, constipation, diarrhea, epigastric discomfort, flatulence, hepatic abnormalities, indigestion, nausea, thirst, vomiting

GU: Darkened urine, dysuria, increased vaginal discharge, menorrhagia, UTI, vaginal candidiasis or odor, vulvo-vaginal discomfort

HEME: Reversible thrombocytopenia, transient leukopenia or neutropenia MS: Arthralgia, arthritis, myalgia, pelvic pain

RESP: Bronchospasm, dyspnea, upper respiratory tract infection

SKIN: Diaphoresis, erythema multiforme, flushing, pruritus, rash, StevensJohnson syndrome, urticaria Other: Angioedema 

Patient And Carer Advice: