Clinical Pharmacology Details


SECNIDAZOLE


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Indications & Dose:


Adults


Intestinal amoebiasis & giardiasis:


1 day treatment 2g as single once only dosage.


Adult Single dose of 4 tabs or 2 Forte tabs. Sexual partner should be given same dose.


Children 3mg/kg body wt. single dose. 

Contraindications:

Hypersensitivity.


PREGNANCY: 1st trimester of pregnancy & breastfeeding.

Side Effects:

Anorexia, nausea, glossitis, epigastric pain, diarrhea, skin rash, urticaria, leucopenia, fatigue, headache. 

Cautions:

Alcohol during treatment.  1st trimester of pregnancy. 

Precautions:

Neurological disorders, liver dysfunction, avoid alcohol.


Old age: Caution, may be given in reduced dose

Interaction:

Drugs


Anticoagulants: May potentiate anticoagulant effect of warfarin; increased risk of hemorrhage.


Disulfiram: Antabuse-like effects.


Cimetidine: Half-life of secnidazole is prolonged.


Lithium: Plasma levels of lithium increased leading to toxicity. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: