Clinical Pharmacology Details


AZITHROMYCIN


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Indications & Dose:

Mild to moderate infections of the upper and lower respiratory tract; uncomplicated skin and skin structure infections; nongonococcal urethritis or cervicitis caused by susceptible organisms; gonococcal urethritis*; chancroid; otitis media; prevention of Mycobacterium avium complex infection in AIDS patients*


DOSE


Adults: Usually 500mg once daily for 3 days taken at least 1 hour before or 2 hours after food. Genital infections. 1000mg as a single dose.


Children: Under 3 years (upto 15kg), 10mg/kg; 3- 7 years: 5ml; 8-11 years; 7.5ml; 12-14 years: 10ml. All as a single daily dose for 3 days, taken at least 1 hour before or 2 hours after food.

Contraindications:

Hypersensitivity to erythromycin

Side Effects:

CV: Chest pain, palpitations


CNS: Dizziness, headache, somnolence, vertigo


GI: Abdominal pain, cholestatic jaundice, diarrhea, dyspepsia, flatulence, heartburn, hepatotoxicity, melena, nausea, stomatitis, vomiting


Gtr: Moniliasis, nephritis, vaginitis


SKIN: Photosensitivity, pruritus, rash, urticaria 

Cautions:

Precautions:

Hepatic, renal, cardiac disease 

Interaction:

Drugs


Penicillins: Azithromycin may inhibit antibacterial activity of penicillins

Warnings:

Adverse Effects:

Lactations:

 Excretion into breast milk unknown 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: