TIGECYCLINE

Indications & Dose:

> To treat complicated skin and skin structure infections caused by Escherichia coli, Enterococcus faecalis (vancomycinsusceptible isolates only), Staphylococcus aureus (methidllin-susceptible and resistant isolates), Streptococcus agalactiae, Streptococcus anginosus group (includes S. anginosus, S. intermedius, and S. constellatus,), Streptococcus pyo-genes, and Bacteroides fragilis; to treat complicated intra-abdominal infections caused by Citrobacter freundii, Enterobacter cloacae, E. coli, Klebsiella oxytoca, Klebsiella pneumoniae, Enterococcus faecalis (vancomycin-suseptible isolates only), S. aureus (methicillin-susceptible isolates only), S. anginosus group, B. fragilis, Bacteroides thetaiotaomicron, Bacteroides unifor-mis, Bacteroides vulgatus, Clostridium perfringens, and Peptostreptococcus micros; to treat community-acquired bacterial pneumonia caused by Streptococcus pneumoniae (penicillin-susceptible isolates), including cases with concurrent bacteremia, Haemophilus influenzae (beta-lactamase negative isolates), and Legionella pneumophila I.V. INFUSION 

Adults. Initial: 100 mg infused over 30 to 60 min followed by 50 mg infused over 30 to 60 min every 12 hr for 5 to 14 days for complicated skin and skin structure infections and intra-abdominal infections (7 to 14 days for community-acquired bacterial pneumonia).

DOSAGE ADJUSTMENT For patients with severe hepatic impairment, initial dosage of 100 mg should be followed by a reduced maintenance dosage of 25 mg every 12 hr.

Contraindications:

 Lactations, Pregnancy, Hypersensitivity to tigecycline or its components 

Side Effects:

Cautions:

Precautions:

Renal disease, hepatic disease, cholelethiasis, monitor for signs of acute pancreatitis, consider withdrawal if suspected. Hypersensitivity with Tetracyclines. 

Interaction:

Warnings:

Adverse Effects:

Lactations:

Systemic tetracycline excreted into breast milk in low concentrations; theoretically, dental staining could occur, but serum levels in infants undetectable, so considered compatible with breast feeding 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Asthenia, chills, dizziness, fever, headache, insomnia, somnolence

CV: Bradycardia, hypertension, hypotension, peripheral edema, phlebitis, septic shock, tachycardia, thrombophlebitis, vasodilation

EENT: Dry mouth, taste perversion

ENDO: Hyperglycemia, hypoglycemia

GI: Abdominal pain, acute pancreatitis, anorexia, constipation, diarrhea, dyspepsia, elevated liver enzyme levels, hepatic dysfunction or failure, jaundice, nausea, pancreatitis, pseudomembranous colitis, vomiting

GU: Elevated BUN and creatinine levels, vaginal candidiasis

HEME: Anemia, increased PT, leukocytosis, thrombocythemia

MS: Back pain

RESP: Increased cough, dyspnea

SKIN: Diaphoresis, photosensitivity, pruritus, rash

Other: Anaphylaxis, hypersensitivity reaction, hypocalcemia; hypokalemia; hyponatremia; hypoproteinemia; injection-site reaction, such as edema, phlebitis, inflammation, and pain

Patient And Carer Advice: