PIPERACILLIN/ TAZOBACTAM

Indications & Dose:

Infections of the respiratory and genitourinary tract, bone; skin and intra-abdominal infections; gonococcal infections; septicemia caused by susceptible organisms; combination with tazobactam effective against Blactamase producing strains, moderate to severe nosocomial pneumonia

DOSE

Adults

4.5gm by slow i.v injection or infusion eight hourly.

Children

Not recommended

Contraindications:

Side Effects:

Cautions:

Precautions:

Hypersensitivity to cephalosporins; CHF; children < 12 yr

Interaction:

Drugs

Aminoglycosides: Carbenicillin and other piperacillins can inactivate aminoglycosides in vitro and in certain patients with renal dysfunction

Chloramphenicol: Inhibited antibacterial activity of piperacillin; administer piperacillin 3 hr before chloramphenicol

Macrolide antibiotics: Inhibited antibacterial activity of piperacillin; administer piperacillin 3 hr before macrolides 

Methotrexate: Piperacillin in large doses may increase serum methotrexate concentrations

Oral contraceptives: Occasional impairment of oral contraceptive efficacy; consider use of supplemental contraception during cycles in which piperacillin is used etracyclines: Inhibited antibacterial activity of piperacillin; administer piperacillin 3 hr before tetracyclines

Warnings:

Adverse Effects:

Lactations:

 Excreted in breast milk in small concentrations 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anxiety, coma, depression, hallucinations, lethargy, seizures, twitching

GI: Abdominal pain, colitis, diarrhea, glossitis, increased AST, ALT; nausea, vomiting

GU: Glomerulonephritis, hematuria, moniliasis, oliguria, proteinuria, vaginitis

HEME: Anemia, bone marrow depression, inch bleeding time

METAB: Hypernatremia, hypokalemia 

Patient And Carer Advice: