BACAMPICILLIN

Indications & Dose:

Infections of the upper and lower respiratory tract, including acute exacerbations of chronic bronchitis, skin and skin structure, urinary tract infections, and gonorrhea (acute uncomplicated urogenital infections) due to susceptible organisms

DOSE

Adult: • Usual dosage PO 400-800 mg ql2h •

Gonorrhea: (acute uncomplicated urogenital infections due to N. gonorrhea, males and females) 1.6 g (4 x 400 mg tablet plus 1 g ) as a single oral dose

Child: • Usual dosage PO 25-50 mg/kg/day in divided doses q 12h

Contraindications:

 Hypersensitivity to penicillins.

Side Effects:

Cautions:

Precautions:

Superinfections with mycotic or bacterial pathogens, concomitant mononucleosis (high percentage develop a skin rash) 

Interaction:

Drugs

Atenolol: Reduced serum concentration of atenolol

Chloramphenicol: Inhibited antibacterial activity of bacampicillin; administer bacampicillin 3 hours before chloramphenicol

Macrolide antibiotics: Inhibited antibacterial activity of bacampicillin; administer bacampicillin 3 hours before macrolides

Methotrexate: Increased serum methotrexate concentrations

 Oral contraceptives: Occasional impairment of oral contraceptive efficacy; consider use of supplemental contraception during cycles in which bacampicillin is used

Tetracyclines: Inhibited antibacterial activity of bacarnpicillin; administer bacampicillin 3 hours before tetracycline

Warnings:

Adverse Effects:

Lactations:

in milk; milk: plasma ratios up to 0.2 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anxiety, coma, depression, hallucinatons, lethargy, seizures, twitching

GI: Black “hairy” tongue, diarrhea, enterocolitis, gastritis, glossitis, increased AST/ALT, nausea, pseudomembranous colitis, stomatitis, vomiting

GU: Glomerulonephritis, hematuria, moniliasis, oliguria, proteinurea, vaginitis

HEME: Anemia, bone narrow depression, granulocytopenia, increased bleeding time, thrombocytopenia, thrombocytopenic purpura, eosinophilia, leukopenia, and agranulocytosis (Hypersensitivity phenomena)

MISC.: Hypersensitivity reactions (skin rashes, urticaria, erythema multiform, and an occasional case of exfoliative dermatitis; skin rash when given with allopurinol), serious and occasional fatal hypersensitivity (anaphylactic) 

Patient And Carer Advice: