AMPICILLIN + SULBACTAM

Indications & Dose:

Treatment of infections due to susceptible strains of the designated microorganisms in the conditions listed below. Skin and Skin Structure Infections caused by beta-lactamase producing strains of Staphylococcus aureus, Escherichia coli, Klebsiella spp. (including K. pneumoniae), Proteus mirabilis,Bacteroides fragilis,Enterobacter spp. and Acinetobacter calcoaceticus. Intra-Abdominal Infections caused by betalactamase producing strains of Escherichia coli, Klebsiella spp. (including K. pneumoniae),m Bacteroides spp. (including B. fragilis), and Enterobacter spp. Gynecological Infections caused by betalactamase producing strains of Escherichia coli,and Bacteroides spp (including B. fragilis).

DOSAGE:

Adult: The recommended adult dosage is 1.5 g (1 g ampicillin as the sodium salt plus 0.5 g sulbactam as the sodium salt) to 3 g (2 g ampicillin as the sodium salt plus 1 g sulbactam as the sodium salt) every six hours.

Pediatric Patients 1 Year of Age or Older: 300 mg per kg of body weight administered via intravenous infusion in equally divided doses every 6 hours. This 300 mg/kg/day dosage represents the total ampicillin content plus the sulbactam content of this molucule, and corresponds to 200 mg ampicillin/ 100 mg sulbactam per kg per day.

The safety and efficacy administered via intramuscular injection in pediatric patients have not been established. Pediatric patients weighing 40 kg or more should be dosed according to adult recommendations, and the total dose of sulbactam should not exceed 4 grams per day. The course of intravenous therapy should not routinely exceed 14 days. In clinical trials, most children received a course of oral antimicrobials following initial treatment with intravenous

Contraindications:

in conditions like Lymphoma, Glandular fever, Hypersensitivity 

Side Effects:

Local Adverse Reactions, Pain at IM injection site 16%, Pain at IV injection site 3%, Thrombophlebitis 3% Systemic Adverse Reactions diarrhea in 3% of the patients and rash in less than 2% of the patients.

Hepatic: Increased AST (SGOT), ALT (SGPT), alkaline phosphatase, and LDH.

Hematologic: Decreased hemoglobin, hematocrit, RBC, WBC, neutrophils, lymphocytes, platelets and increased lymphocytes, monocytes, basophils, eosinophils, and platelets. Blood Chemistry: Decreased serum albumin and total proteins.

Renal: Increased BUN and creatinine.

Urinalysis: Presence of RBCs and hyaline casts in urine.

Gastrointestinal: Gastritis, stomatitis, black “hairy” tongue and enterocolitis. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment.

Hypersensitivity Reactions: Urticaria, erythema multiforme, and an occasional case of exfoliative dermatitis have been reported. These reactions may be controlled with antihistamines and, if necessary, systemic corticosteroids. Whenever such reactions occur, the drug should be discontinued, unless the opinion of the physician dictates otherwise. Serious and occasional fatal hypersensitivity (anaphylactic) reactions can occur with a penicillin

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Counselling:

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