CEFEPIME

Indications & Dose:

Infections of the urinary (including pyelonephritis) and lower respiratory (pneumonia) tracts and skin and skin structure infections, including cases associated with bacteremia caused by susceptible organisms, empiric monotherapy for febrile neutropenia in pediatric patients 

DOSE

Adult

I.M/I.V: When giving IV, infuse over 30 minutes. Pneumonia: 1-2g IV every 12 hrs for 10 days. Skin and skin structures, severe UTIs: 2g IV every 12 hrs for 10 days. Mild-to-moderate for 7-10 days (IM only for UTIs caused by E. coli). Intraabdominal *use w. metronidazole): 2g IV every 12 hrs for 7- 10 days. Febrile neutropenia: 2g IV every 8 hrs for 7 days or until neutropenia resolves. Hemodialysis; repeat initial dose after each session. Continuous ambulatory peritoneal dialysis; give usual doses at 48-hour intervals.

Child 2 mo-16 yrs

• <40 kg: 50 mg/kg IV q 12h (q8h for febrile neutropenia) x 7-10 days

Contraindications:

Side Effects:

Cautions:

Precautions:

Hypersensitivity to penicillins, decreased prothrombin activity 

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity

Loop diuretics: Increased nephrotoxicity

Oral anticoagulants: Potential increase. in hypoprothrombinemic response to oral anticoagulants

Warnings:

Adverse Effects:

Lactations:

 Excreted into breast milk in very low concentrations (0.5 μg/ml) 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Encephalopathy (in renally impaired .without dosage reduction), seizures

CV: Thrombophlebitis

EENT: Oral candidiasis

GI: Abdominal cramps, diarrhea, hepatic dysfunction including cholestasis, nausea, pseudomembranous colitis, vomiting

GU: Renal dysfunction, nephrotoxicity, vaginitis

HEME: Bone marrow suppression, hemolytic anemia, hemorrhage, hypoprothrombinemia

SKIN: Erythema multiform, StevensJohnson syndrome, toxic epidermal necrolysis

MISC.: Serum sickness-like reactions

Patient And Carer Advice: