Ceftazidime

Indications & Dose:

Prophylaxis for transurethral resection of prostate

• BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult: 1 g, single dose to be administered up to 30 minutes before procedure and may be repeated if necessary when catheter removed

Pseudomonal lung infection in cystic fibrosis 

• BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult: 100–150 mg/kg daily in 3 divided doses; maximum 9 g per day Complicated urinary-tract infection 

• BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult 18–79 years: 1–2 g every 8–12 hours

Adult 80 years and over: 1–2 g every 8–12 hours; maximum 3 g per day

Septicaemia | Hospital-acquired pneumonia 

• BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult 18–79 years: 2 g every 8 hours

Adult 80 years and over: 2 g every 8 hours; maximum 3 g per day

Febrile neutropenia

• BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult 18–79 years: 2 g every 8 hours

Adult 80 years and over: 2 g every 8 hours; maximum 3 g per day Meningitis 

• BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult 18–79 years: 2 g every 8 hours

Adult 80 years and over: 2 g every 8 hours; maximum 3 g per day

Susceptible infections due to sensitive Grampositive and Gram-negative bacteria 

• BY INTRAVENOUS INFUSION, OR BY INTRAVENOUS INJECTION, OR BY DEEP INTRAMUSCULAR INJECTION

Adult 18–79 years: 1–2 g every 8 hours Adult 80 years and over: 1–2 g every 8 hours; maximum 3 g per day

child 1 mo-12 yr

IV 30-100 mg/kg- q8h, not to exceed 6 g/day

Neonates 0-4 wk

IV 30 mg/kg q 12h

Contraindications:

Side Effects:

Paraesthesia . taste disturbances

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Anorexia, bleeding; diarrhea, glossitis, increased LFTs, nausea pseudomembranous colitis, vomiting

GU: Candidiasis, nephrotoxicity, proteinuria, vaginitis

HEME: Bone marrow suppression, eosinophilia, hemolytic anemia, lymphocytosis

RESP: Dyspnea

SKIN: Dermatitis, rash, urticaria 

PREGNANCY Not known to be harmful.

 BREAST FEEDING Present in milk in low concentration, but appropriate to use.

 HEPATIC IMPAIRMENT Manufacturer advises caution in severe impairment.

 RENAL IMPAIRMENT Reduce dose if eGFR less than 50 mL/minute/1.73m2—consult product literature.

Cautions:

Precautions:

Interaction:

Drugs

Aminogl ycosides: Additive nephrotoxicity

Chloramphenicol: Inhibition of the antibacterial activity of ceftazidime

Loop diuretics: Increased nephrotoxicity 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: