Cefotaxime

Indications & Dose:

Uncomplicated gonorrhoea 

• BY INTRAMUSCULAR INJECTION

Adult: 500 mg for 1 dose

Infections due to sensitive Gram-positive and Gramnegative bacteria

Surgical prophylaxis

Haemophilus epiglottitis

•  BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION

Adult: 1 g every 12 hours Severe susceptible infections due to sensitive Grampositive and Gram-negative bacteria |

Meningitis 

• BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INJECTION, OR BY INTRAVENOUS INFUSION

Adult: 8 g daily in 4 divided doses, increased if necessary to 12 g daily in 3–4 divided doses, intramuscular doses over 1 g should be divided between more than one site continued Emergency treatment of suspected bacterial meningitis or meningococcal disease, before urgent transfer to hospital, in patients who cannot be given benzylpenicillin (e.g. because of an allergy) 

• BY INTRAVENOUS INJECTION, OR BY INTRAMUSCULAR INJECTION

Child 1 month–11 years: 50 mg/kg for 1 dose

Child 12–17 years: 1 g for 1 dose

Adult: 1 g for 1 dose

Contraindications:

Side Effects:

Cautions:

Precautions:

Hypersensitivity to penicillins

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity .

Chloramphenicol: Inhibits antibacterial activity of cidalcefotaxime.

Oral anticoagulants: Hypoprothrombinemia

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased AST, ALT, bilirubin, LDH, alk phosphatase; nausea, pain, pseudomembranous colitis, vomiting

GU: Candidiasis, proteinuria, pruritus, vaginitis, nephrotoxicity

HEME: Bone marrow suppression, eosinophilia, hemolytic anemia, lymphocytosis

SKIN: Dermatitis, induration (IM), inflammation (IV), pain, rash, urticaria

PREGNANCY Not known to be harmful.

 BREAST FEEDING Present in milk in low concentration, but appropriate to use.

 RENAL IMPAIRMENT ¶% In adults If eGFR less than 5 mL/minute/ 1.73m2, initial dose of 1 g then use half normal dose. ¶% In children Usual initial dose, then use half normal dose if estimated glomerular filtration rate less than 5 mL/minute/1.73m2

Patient And Carer Advice: