CEFOPERAZONE SODIUM

Indications & Dose:

Infections of the lower respiratory tract, urinary tract, skin; bone infections, septicemia, peritonitis, PID caused by susceptible organism

DOSE

Adult:

• Mild/moderate infections: IM/IV 1-2 g q 12h

• Severe infections: IM/IV 6-12 g/day divided in 2-4 equal doses

• Hepatic disease or biliary obstruction: Doses >4 g/day generally not necessary

Children: 50-200mg/kg/day in 2 divided doses (every 12 hours). Increased frequency or higher doses (300mg/kg/day) may be used for treating very severe infections (like bacterial meningitis).

• Neonates: 50 mg/kg/dose q 12h

Contraindications:

 Infants < 1 mo. 

Side Effects:

Cautions:

Precautions:

 Hypersensitivity to penicillins 

Interaction:

Drugs

Aminoglycosides: Increased risk of nephrotoxicity

Ethanol: Disulfiram-like reactions

Loop diuretics: Increased nephrotoxicity oral anticoagulants: Via hypoprothrombinemia, may enhance anticoagulant effects

Labs

• Creatinine: Increased serum values

SPECIAL CONSIDERATIONS

• No dose adjustment necessary in renal failure when usual doses are administered

Warnings:

Adverse Effects:

Lactations:

Low concentrations excreted in human milk 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased LFTs nausea, pseudomembra nous colitis, vomiting

GU: Candidiasis, nephrotoxicity, proteinuria, vaginitis

HEME: Bone marrow suppression, anemia, bleeding, eosinophilia, hemolytic anemia, hypoprothrombinemia, leukopenia, lymphocytosis,

RESP: Dyspnea SKIN: Dermatitis, rash, urticaria

Patient And Carer Advice: