CEFDINIR

Indications & Dose:

Adult and CHild > 16 yr

• Upper respiratory infections:

PO 600 mg q24h x 10 days

• Lower respiratory infections,

skin/skin structure infections: PO 300 mg q12h x 10 days

• Renal failure:

CrCl <30 ml/min, 300 mg qd

Child > 6 mo

• PO 14 mg/kg q24h to max 60 mg qd (qd dosing not studied in skin infections, 7 mg/kg q12h recommended)

• Renal failure: CrCl < 30 ml/min, 7 mg/kg qd (max300mg)

Contraindications:

Side Effects:

CNS: Headache

GI: Pseudomembranous colitis, red stools (not significant, formed by a complex of cefdinir and iron), diarrhea (16%), nausea, dyspepsia, flatulence, elevated LFTS

GU: Monilial vaginitis, renal failure

HEME: Bone marrow suppression

SKIN: Stevens-Johnson syndrome 

Cautions:

Precautions:

Hypersensitivity to penicillins, renal disease 

Interaction:

Drugs

Antacids, Iron: Interference with cefdinir absorption, take antibiotic 2 hr before or after (can be administered with iron fortified infant formula)

Probenecid: Inhibits cefdinir excretion

Live typhoid vaccine: Interference at least 24 hr after last dose  

Warnings:

Adverse Effects:

Lactations:

Pregnancy category B: not detected in human milk after administration of single 600 mg dose 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: