CEFPODOXIME PROXETIL

Indications & Dose:

Infections of the upper and lower respiratory tract, skin and skin structure, urinary tract; sexually transmitted diseases (uncomplicated urethral and cervical gonorrhea)

DOSE

Adult

Lower respiratory tract infection: 100-200 mg twice daily

Upper respiratory tract infection: 100 mg twice daily

Pneumonia: 200 mg q 12h for 14 days

Uncomplicated gonorrhea: 200mg single dose

Skin and shin structure: 400 mg q 12h for 7-14 days

Pharyngitis and tonsillitis: 100 mg q 12h for 10 days

Sinusitis: 200 mg twice daily

Lower UTI: 100 mg twice daily

Upper UTI: 200 mg twice daily

Uncomplicated UTI: 100 mg q12h for 7 days

Renal failure: Increase dosing interval to q24h for

CrCI <30 ml/min

Children

Under 6 months: 8mg/kg daily in two divided doses

6 months-2years: 5ml twice daily

3-8 years: 10ml twice daily

Over 9 years: 12.5 or 1 tablet twice daily

Contraindications:

Infants

Side Effects:

Cautions:

Precautions:

Hypersensitivity to penicillins, renal disease

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity

Antacids: Reduced bioBrands Available with Costand serum cefpodoxime levels

H2-blockers (cimetidine, famotidine, nizatidine, ranitidine), proton pump blockers (lansopra-zole, omeprazole): Reduced bioBrands Available with Cost and serum cefpodoxime levels

Loop diuretics: Increased nephrotoxicity 

Warnings:

Adverse Effects:

Lactations:

into breast Milk; average 2% of serum levels at 4 hr following 200mg dose 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, dizziness, fatigue, fever, headache, lethargy, paresthesia

GI: Anorexia, bleeding; diarrhea, glossitis, increased LFTs; nausea, pseudomembranous coliis, vomiting

GU: Candidiasis, nephrotoxicity, vaginitis

HEMS: Bone marrow suppression, eosinophilia, hemolytic anemia, lymphocytosis

RESP: Dyspnea

SKIN: Dermatitis, rash, urticaria

Patient And Carer Advice: