Cefradine

Indications & Dose:

Susceptible infections due to sensitive Grampositive and Gram-negative bacteria

Surgical prophylaxis

DOSE 

• BY MOUTH 

Adult: 1-2gm daily in 2 or 4 divided doses, max; 4gm daily.

Children:  25-50 mg/kg daily in 2 or 4 divided doses

Otitismedia:

75-100mg/kg daily in divided doses every 6-12 hours, max; 4gm daily.

Continue in all cases for 48-72 hours after patient is a symptomatic

• BY Inj

Adult:

2-4gm IM, IV or IV infusion daily in divided doses, max; 8gm daily.

Surgical prophylaxis; 1-2gm IM, IV, as a single dose pre.operatively

Children:

50-100mg/kg daily in 4 divided doses Continue in all cases for 48-72 hours after patient is a symptomatic 

Contraindications:

Side Effects:

Cautions:

Precautions:

Hypersensitivity to penicillins, renal disease

PREGNANCY Not known to be harmful.

BREAST FEEDING Present in milk in low concentration, but appropriate to use.

RENAL IMPAIRMENT In adults Use half normal dose if eGFR 5–20 mL/minute/1.73m2. Use one-quarter normal dose if eGFR less than 5 mL/minute/1.73m2.  In children Reduce dose if estimated glomerular filtration rate less than 20 mL/minute/ 1.73m2. 

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity 

Loop diuretics: Increased nephrotoxicity

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased LFTs; nausea, pseudomembranous colitis, vomiting

GU: Candidiasis, nephrotoxicity, proteinuria, pruritus, vaginitis

HEMS: Bone marrow suppression, eosinophilia, hemolytic anemia, lymphocytosis

RESP: Dyspnea

SKIN: Dermatitis, rash, urticaria 

Patient And Carer Advice: