CEFADROXIL

Indications & Dose:

Susceptible infections due to sensitive Gram positive and Gram-negative bacteria 

• BY MOUTH

Child 6–17 years (body-weight up to 40 kg): 0.5 g twice daily 

Child 6–17 years (body-weight 40 kg and above): 0.5–1 g twice daily 

Adult: 0.5–1 g twice daily

Skin infections

Soft-tissue infections

Uncomplicated urinary-tract infections 

• BY MOUTH

Child 6–17 years (body-weight 40 kg and above): 1 g once daily 

Adult: 1 g daily.

Children: Below 1 year: 25mg/kg body-wt. daily in 2 divided doses. 1-6 years: 250mg twice daily. Above 6 years: 500mg twice daily. 

Contraindications:

Infants < 1 mo.]

 PREGNANCY Not known to be harmful.

BREAST FEEDING Present in milk in low concentration, but appropriate to use.

 RENAL IMPAIRMENT % In adults 1 g initially, then 500mg every 12 hours if eGFR 26–50 mL/minute/1.73m2. 1 g initially, then 500mg every 24 hours if eGFR 11–26 mL/minute/ 1.73m2. 1 g initially, then 500mg every 36 hours if eGFR less than 11 mL/minute/1.73m2. 

In children Reduce dose if estimated glomerular filtration rate less than 50 mL/minute/ 1.73m2.

Side Effects:

Cautions:

Precautions:

Hypersensitivity to penicillins

Interaction:

Drugs

Aminoglycosides: Additive nephrotoxicity

Loop diuretics: Increased nephrotoxicity 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Chills, dizziness, fever, headache, paresthesia, weakness

GI: Abdominal pain, anorexia, bleeding; diarrhea, glossitis, increased LFTs, nausea, pseudomembranous colitis, vomiting

GU: Candidiasis, nephrotoxicity, proteinuria, pruritus, vaginitis

HEME: Bone marrow suppression, eosinophilia, hemolytic anemia, lymphocytosis

RESP: Dyspnea

SKIN: Dermatitis, rash, urticaria 

Patient And Carer Advice: