Cephalosporins

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 Rare Antibiotic-associated colitis % Frequency not known Abdominal discomfort . agranulocytosis . allergic reactions . anaphylaxis . aplastic anaemia . blood disorders . confusion . diarrhoea . disturbances in liver enzymes . dizziness . eosinophilia . haemolytic anaemia . hallucinations . headache . hyperactivity . hypertonia . leucopenia . nausea . nervousness . pruritus . rashes . reversible interstitial nephritis . serum sickness-like reactions with rashes, fever and arthralgia . sleep disturbances . StevensJohnson syndrome . thrombocytopenia . toxic epidermal necrolysis . transient cholestatic jaundice . transient hepatitis . urticaria . vomiting SIDE-EFFECTS, FURTHER INFORMATION % Antibiotic-associated colitis Antibioticassociated colitis may occur more commonly with second- and third-generation cephalosporins. l ALLERGY AND CROSS-SENSITIVITY Contraindicated in patients with cephalosporin hypersensitivity. % Cross-sensitivity with other beta-lactam antibacterials About 0.5–6.5% of penicillinsensitive patients will also be allergic to the cephalosporins. Patients with a history of immediate hypersensitivity to penicillin and other betalactams should not receive a cephalosporin. Cephalosporins should be used with caution in patients with sensitivity to penicillin and other betalactams

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