Indications & Dose:
Tuberculosis, resistant to other treatment, in combination with other drugs
Adult: 15 mg/kg daily (max. per dose 1 g), reduce dose in those under 50 kg and those over 40 years
Adjunct to doxycycline in brucellosis (administered on expert advice)
Brucellosis
1 g/day for 14-21 days (with doxycycline, 100 mg twice daily for 6 weeks)
Endocarditis:
Enterococcal: 1 g every 12 hours for 2 weeks, 500 mg every 12 hours for 4 weeks in combination with penicillin Streptococcal: 1 g every 12 hours for 1 week, 500 mg every 12 hours for 1 week
Mycobacterium avium complex:
Adjunct therapy (with macrolide, rifamycin, and ethambutol): 15 mg/ kg 3 times/week for first 2-3 months for severe disease
Plague:
15 mg/kg (or 1 g) every 12 hours until the patient is afebrile for at least 3 days
Tuberculosis:
Daily therapy: 15 mg/kg/day (maximum: 1 g) Directly observed therapy (DOT): Twice weekly: 25-30 mg/kg (maximum: 1.5 g) Directly observed therapy DOT: 3 times/week: 25-30 mg/kg (maximum: 1.5 g)
Pregnancy Streptomycin crosses the placenta. Many case reports of hearing impairment in children exposed in utero have been published. Impairment has ranged from mild hearing loss to bilateral deafness. Because of several reports of total irreversible bilateral congenital deafness in children whose mothers received streptomycin during pregnancy, the manufacturer classifies streptomycin as pregnancy risk factor D.
Contraindications:
Side Effects:
Frequency not known Hypersensitivity reactions paraesthesia of mouth
RENAL IMPAIRMENT Should preferably be avoided. If essential, use with great care and consider dose reduction.
Cautions:
Precautions:
Interaction:
Avoid Concomitant Use
Avoid concomitant use of Streptomycin with any of the following: Gallium Nitrate Increased Effect/ Toxicity
Streptomycin may increase the levels/effects of: Bispho-sphonate Derivatives; Botulinum Toxin Type A; Botulinum Toxin Type B; CARBOplatin; Colistimethate; Cyclo-SPORINE; Gallium Nitrate; Neuromuscular-Blocking Agents
The levels/effects of Streptomycin may be increased by: Amphotericin B; Capreomycin; CISplatin; Loop Diuretics; Nonsteroidal Anti-Inflammatory Agents; Vancomycin Decreased Effect
Streptomycin may decrease the levels/effects of:
Typhoid Vaccine
The levels/effects of Streptomycin may be decreased by: Penicillins
Warnings:
Adverse Effects:
Lactations:
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
Patient And Carer Advice:
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