FURAZOLIDONE

Indications & Dose:

Bacterial or protozoal diarrhea and enteritis caused by susceptible organisms Antimicrobial spectrum usually includes:

•  Gram-positive organisms: Staphylococci


• Gram-negative organisms: E. coli, Salmonella, Shigella, Proteus, Enterobacter aerogenes, Vibrio cholerae; protozoan organisms: Giardia lamblia

BY MOUTH

Adults : 1 tab. or 20ml 8 hourly.

Typhoid: 2 tabs 3-4 times daily.

Children : Over 5 years 1/2 tab or 10ml 8 hourly; below 5 years 1/4 tab or 2.5 to 5ml. All for 3-7 days or as required.

Contraindications:

Infants < 1 mo 

Side Effects:

CNS: Fever, headache, malaise

CV: Hypertensive crisis, orthostatic hypotension

GI: Anal pruritus, colitis, nausea, proctitis, staphylocaccic enteritis, vomiting

HEME: Hemolysis in G-6-PD deficiency

METAB: Hypoglycemia

MS: Arthralgia

SKIN: Vesicular morbilliform rash

Cautions:

Precautions:

 Hypertension, diabetes, G-6-PD deficiency 

Interaction:

Drugs

Amphetamines: Hypertensive crisis

Ephedrine: Hypertensive response

Ethanol: Disulfiram-like reaction

Foods high in amine content Hypertensive crisis

Phenylpropanolamine: Hypertensive response 

Warnings:

Adverse Effects:

Lactations:

Pregnancy category C; could theoretically produce hemolytic anemia in a G-6-PD deficient newborn if given at term; excretion into breast milk unknown; use caution in nursing mothers 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: