Clinical Pharmacology Details


SEVOFLURANE


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Indications & Dose:

Induction of anaesthesia (in oxygen or nitrous oxide– oxygen)



Adult: Initially 0.5–1 %, then increased to up to 8 %, increased gradually, according to response, to be administered using specifically calibrated vaporiser Maintenance of anaesthesia (in oxygen or nitrous oxide– oxygen)



Adult: 0.5–3 %, adjusted according to response, to be administered using specifically calibrated vaporiser 

Contraindications:

Susceptibility to malignant hyperthermia 

Side Effects:

Also agitation occurs frequently in children


PREGNANCY May depress neonatal respiration if used during delivery.


BREAST FEEDING Breast-feeding can be resumed as soon as mother has recovered sufficiently from anaesthesia.


RENAL IMPAIRMENT Use with caution.


PATIENT AND CARER ADVICE


Driving and skilled tasks


Patients given sedatives and analgesics duringminor outpatient procedures should be very carefully warned about the risk of driving or undertaking skilled tasks afterwards. For a short general anaesthetic the risk extends to at least 24 hours after administration. Responsible persons should be available to take patients home. The dangers of taking alcohol should also be emphasised.

Cautions:

Susceptibility to QT-interval prolongation 

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: