VARENICLINE TARTRATE

Indications & Dose:

To aid smoking cessation

•  BY MOUTH

Adult: Initially 500 micrograms once daily for 3 days, increased to 500 micrograms twice daily for 4 days, then 1 mg twice daily for 11 weeks; reduced if not tolerated to 500 micrograms twice daily, usually to be started 1–2 weeks before target stop date but can be started up to a maximum of 5 weeks before target stop date, 12-week course can be repeated in abstinent individuals to reduce risk of relapse 

Contraindications:

Hypersensitivity to varenicline or its components 

Side Effects:

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Abnormal dreams, agitation, anxiety, asthenia, attention difficulties, behavior changes, delusions, depression, dizziness, dysgeusia, fatigue, hallucinations, headache, homicidal ideation, hostility, insomnia, irritability, lethargy, loss of consciousness, malaise, mania, mental impairment, panic, paranoia, psychosis, restlessness, sensory disturbances, seizures, somnolence, stroke, suicidal ideation, thirst

CV: Angina, chest pain, edema, hypertension, MI, peripheral ischemia, thrombosis, ventricular extrasystole

EENT: Dry mouth, epistaxis, gingivitis, rhinorrhea

ENDO: Hot flashes

GI: Abdominal pain, acute pancreatitis, anorexia, constipation, diarrhea, dyspepsia, flatulence, gastroesophageal reflux disease, GI hemorrhage, increased appetite, liver enzyme abnormalities, nausea, vomiting

GU: Acute renal failure, polyuria, urine retention

HEME: Leukocytosis, lymphadenopathy, splenomegaly, thrombocytopenia

RESP: Asthma, dyspnea, pulmonary embolism

MS: Arthralgia, back pain, muscle cramp, musculoskeletal pain, myalgia

SKIN: Diaphoresis, erythema multiforme, pruritus, rash, Stevens-Johnson syndrome, urticaria

Other: Angioedema, flulike syndrome hyperkalemia, hypersensitivity, hypokalemia

Patient And Carer Advice: