NITRAZEPAM

Indications & Dose:

Insomnia (short-term use)

  BY MOUTH

Adult: 5–10 mg daily, dose to be taken at bedtime, for debilitated patients, use elderly dose

Elderly: 2.5–5 mg daily, dose to be taken at bedtime.

Contraindications:

Side Effects:

Anorexia, nausea, sedation, nightmares, fatigue, blurring of vision, dry mouth, paradoxical excitement and sweating.

Cautions:

Precautions:

Respiratory depression

Old age: may be given in reduced dose

. Pregnancy & Breast-feeding: Use with cautions 

Interaction:

Drugs

Cimetidine, Oral contraceptives, Disulfiram, fluoxetine, Isoniazid, Ketoconazole, Metoprolol, Propoxyphene, Propranolol, Valporic acid: Elimination of nitrazepam decreased due to inhibition of hepatic metabolism leading to enhanced activity.

Alcohol & other CNS depression: Enhanced CNS effects.

Digoxin: Increase in serum concentration of digoxin.

Levodopa: Decrease in antiparkinsonism efficacy.

Imipramine & Desipramine: Enhanced activity of these drugs.

Aminophylline: Antagonizes the sedative effect.

Rifampicin: Decreases efficacy.

Ranitidine: Decreases GI absorption of nitrazepam. 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: