ESTAZOLAM

Indications & Dose:

Insomnia

• BY MOUTH

Adult: Neurosis; 1-2mg daily Psychosis & schizophrenia.; 2-4mg daily

Children: Not recommended 

Contraindications:

Side Effects:

Cautions:

Precautions:

Renal or hepatic function impairment, elderly, depression, history of drug abuse, abrupt withdrawal, respiratory depression, sleep apnea 

Interaction:

Drugs

Cimetidine: Increased serum benzodiazepine concentrations

Disulfiram: May increase benzodiazepine serum concentrations

Erythromycin: Increased estazolam sedative effects

Ethanol: Enhanced adverse psychomotor effects of benzodiazepines

Rifampin: Reduced serum benzodiazepine concentrations 

Warnings:

Adverse Effects:

Lactations:

cause fetal damage when administered during pregnancy; excreted into breast milk; may accumulate in breast fed infants and is therefore not recommended 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Abnormal thinking, agitation, amnesia, anxiety, apathy, asthenia, ataxia, decreased libido, decreased reflexes, emotional lability, hangover, hostility, hypokinesia, neuritis, seizures, sleep disorder, sorrinulence, stupor, twitch

CV: Dysrhythmia, syncope

EENT: Ear pain; epistaxis, eye irritation, pain, pharyngitis, photophobia, rhinitis, sinusitis, swelling

GI: Abdominal pain, appetite changes; dyspepsia; enterocolitis, flatulence, gastritis, increased AST, melena, mouth ulceration

GU: Frequent urination, hematuria, menstrual cramps; nocturia, oliguria, penile discharge, urinary hesitancy, urgency; urinary incontinence, vaginal discharge, itching

HEME: Agranulocytosis

MS: Back pain, lower extremity pain

RESP: Asthma, cold symptoms, cough, dyspnea, hyperventilation

SKIN: Acne, dry skin, photosensitivity, urticaria 

Patient And Carer Advice: