CLORAZEPATE DIPOTASSIUM

Indications & Dose:

Anxiety disorders, acute alcohol withdrawal, partial seizures (adjunctive therapy)

• BY MOUTH

Adult 7.5-22.5 mg daily in 2-3 divided doses or a single dose of 15 mg at bedtime

Elderly (or debilitated) half adult dose

Children 9-12 years initially: 3.75-7.5mg/dose twice daily, increase 3.75mg at weekly intervals. Not exceed to 60mg/day. 

Contraindications:

Narrow-angle glaucoma, psychosis 

Side Effects:

Cautions:

Precautions:

Elderly, debilitated, hepatic disease, renal disease, long-term use, history of drug abuse 

Interaction:

Drugs

Cimetidine: Increased plasma levels of clorazepate and/or active metabolites

Disulfiram: Increased serum clorazepate concentrations

Ethanol: Enhanced adverse psychomotor side effects of benzodiazepines

Rifampin: Reduced serum clorazepate concentrations 

Warnings:

Adverse Effects:

Lactations:

 Excreted into breast milk; drug and metabolites may accumulate to toxic levels in nursing infant 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anterograde amnesia, anxiety, ataxia, confusion, depression, dizziness, drowsiness, fatigue, hallucinations, headache, hysteria, insomnia, psychosis, slurred speech, stimulation, tremor

CV: Bradycardia, cardiovascular collages, hypertension, hypotension, orthostatic, tachycardia

EENT: Auditory disturbances, blurred vision, mydriasis, nystagmus

GI: Anorexia, constipation, diarrhea, dry mouth, nausea, vomiting

GU: Changes in libido, incontinence, menstrual irregularities, urinary retention

SKIN: Dermatitis, hair loss, hirsutism, itching, rash, urticaria 

Patient And Carer Advice: