ONDANSETRON

Indications & Dose:

Moderately emetogenic chemotherapy or radiotherapy

  BY MOUTH

Adult: Initially 8 mg, dose to be taken 1–2 hours before treatment, then 8 mg every 12 hours for up to 5 days

  BY RECTUM

Adult: Initially 16 mg, dose to be taken 1–2 hours before treatment, then 16 mg daily for up to 5 days

 INITIALLY BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION Adult: Initially 8 mg, dose to be administered immediately before treatment, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days

 INITIALLY BY INTRAMUSCULAR INJECTION, OR BY INTRAVENOUS INFUSION Elderly: Initially 8 mg, dose to be administered immediately before treatment, intravenous infusion to be given over at least 15 minutes, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days Severely emetogenic chemotherapy (consult product literature for dose of concomitant corticosteroid)

 BY MOUTH

Adult: 24 mg, dose to be taken 1–2 hours before treatment, then 8 mg every 12 hours for up to 5 days

  BY RECTUM Adult: 16 mg, dose to be administered 1–2 hours before treatment, then 16 mg daily for up to 5 days

 INITIALLY BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION

  Adult: Initially 8 mg, dose to be administered immediately before treatment, followed by (by intramuscular injection or by slow intravenous injection) 8 mg every 4 hours if required for 2 doses, alternatively, followed by (by continuous intravenous infusion) 1 mg/hour for up to 24 hours, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days

  INITIALLY BY INTRAMUSCULAR INJECTION Adult 65–74 years: Initially 8 mg, to be given immediately before treatment, followed by (by intramuscular injection) 8 mg every 4 hours if required for 2 doses, alternatively, followed by (by continuous intravenous infusion) 1 mg/hour for up to 24 hours, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days

 INITIALLY BY INTRAVENOUS INFUSION

Adult: Initially 16 mg, immediately before treatment (over at least 15 minutes), followed by (by intramuscular injection or by slow intravenous injection) 8 mg every 4 hours if required for 2 doses, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days Adult 65–74 years: Initially 8–16 mg, immediately before treatment (over at least 15 minutes), followed by (by intramuscular injection or by intravenous infusion) 8 mg every 4 hours if required for 2 doses, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days Adult 75 years and over: Initially 8 mg, immediately before treatment (over at least 15 minutes), followed by (by intravenous infusion) 8 mg every 4 hours if required for 2 doses, then (by mouth) 8 mg every 12 hours for up to 5 days, alternatively (by rectum) 16 mg daily for up to 5 days Prevention of postoperative nausea and vomiting

 INITIALLY BY MOUTH Adult: 16 mg, dose to be taken 1 hour before anaesthesia, alternatively (by intramuscular injection or by slow intravenous injection) 4 mg, dose to be administered at induction of anaesthesia Treatment of postoperative nausea and vomiting

 BY INTRAMUSCULAR INJECTION, OR BY SLOW INTRAVENOUS INJECTION

Adult: 4 mg for 1 dose

Contraindications:

Side Effects:

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: