AMANTADINE hydrochloride

Indications & Dose:

Parkinson’s disease

• BY MOUTH

Adult: 100 mg daily for 1 week, then increased to 100 mg twice daily, usually administered in conjunction with other treatment. Some patients may require higher doses; maximum 400 mg per day

Elderly: 100 mg daily, adjusted according to response

Post-herpetic neuralgia

• BY MOUTH

Adult: 100 mg twice daily for 14 days (continued for another 14 days if necessary)

Treatment of influenza A (but not recommended)

•  BY MOUTH

Adult: 100 mg daily 4–5 days

Prophylaxis of influenza A (but not recommended)

• BY MOUTH

Adult: 100 mg daily usually for 6 weeks or with influenza vaccination for 2–3 weeks after vaccination

• Drug-induced extrapyramidal reactions:

•  BY MOUTH

PO 100 mg bid, increase to 300 mg/day in divided doses if needed 

Contraindications:

 Child < 1 yr 

Side Effects:

Cautions:

Precautions:

 Seizure disorder, CHF, orthostatic hypotension, psychiatric disorders, hepatic disease, renal disease, peripheral edema, eczematoid rash, abrupt discontinuation 

Interaction:

Drugs

Benztropine: Potentiation of amantadine’s CNS side effects

Triamterene: Increased amantadine toxicity

Trihexyphenidyl: Potentiation of amantadine’s CNS side effects 

Warnings:

Adverse Effects:

Lactations:

Excreted in human milk, exercise caution when administering to nursing mothers because of potential for urinary retention, vomiting, and skin rash

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anorexia, anxiety, ataxia, confusion, depression, fatigue, hallucinations, headache, insomnia, light-headedness, psychosis, seizures

CV: CHF, orthostatic hypotension, peripheral edema

EENT: Blurred vision

GI: Constipation, dry mouth, nausea, vomiting

GU: Increased BUN, urinary retention

HEME: Leukopenia

SKIN: Eczematoid dermatitis, livedo reticularis, photosensitivity, rash 

Patient And Carer Advice: