SULPRIDE

Indications & Dose:

Sychoses such as schizophrenia. Tourette’s syndrome, neuroses, vertigo, and gastric and duodenal ulcers but is not one of the main agents usually considered for use in these disorders

• BY MOUTH

Adult:  Oral and parenteral routes in doses ranging from 25 to 300mg daily.

CHILD: under 14 not recommended. 

Contraindications:

Side Effects:

Cautions:

Precautions:

Interaction:

Drugs

Sucralfate, or of an antacid containing aluminium and magnesium hydroxides, in 6 healthy subjects the mean oral bioBrands Available with Cost of sulpiride was reduced by 40 and 32% respectively. When sulpiride was given 2 hours after the antacid or sucralfate (each in 2 subjects) the reduction in bioBrands Available with Cost was about 25%. This interaction was expected to be clinically significant and it was recommended that it used concurrently sulpiride should be given before, rather than with or after, sucralfate or antacids. 

Warnings:

Adverse Effects:

Sleep disturbances, overstimulation, and agitation may occur. The incidence of extrapyramidal disorders appears to be less than that with chlorpromazine, but claims that sulpiride is less likely to cause tardive dyskinesia remain to be established. Sulpiride is less likely to cause sedation than other antipsychotics and antimuscarinic effects are minimal. Cardiovascular effects such as hypotension are generally rare although they may occur with overdosage.

Sulpiride should be given with care to manic or hypomanic patients in whom it may exacerbate symptoms.

Sulpride may be excreted into breast milk in relatively large amounts and some recommend that its use should be avoided in mothers wishing to breast feed. 

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: