Clinical Pharmacology Details


PROCHLORPERAZINE MESYLATE


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Indications & Dose:

Schizophrenia and other psychoses Mania



Adult: 12.5 mg twice daily for 7 days, dose to be adjusted at intervals of 4–7 days according to response; usual dose 75–100 mg daily



Adult: 12.5–25 mg 2–3 times a day


Short-term adjunctive management of severe anxiety



Adult: 15–20 mg daily in divided doses; maximum 40 mg per day


Nausea and vomiting, acute attack



Adult: Initially 20 mg, then 10 mg after 2 hours



Adult: 12.5 mg as required, to be followed if necessary after 6 hours by an oral dose


Nausea and vomiting, prevention



Adult: 5–10 mg 2–3 times a day



Adult: 12.5 mg as required, to be followed if necessary after 6 hours by an oral dose


Prevention and treatment of nausea and vomiting



Child 1–11 years (body-weight 10 kg and above): 250 micrograms/kg 2–3 times a day


Child 12–17 years: 5–10 mg up to 3 times a day if required



Child 2–4 years: 1.25–2.5 mg up to 3 times a day if required


Child 5–11 years: 5–6.25 mg up to 3 times a day if required


Child 12–17 years: 12.5 mg up to 3 times a day if required


Labyrinthine disorders



Adult: 5 mg 3 times a day, increased if necessary to 30 mg daily in divided doses, dose to be increased gradually, then reduced to 5–10 mg daily, dose is reduced after several weeks


Nausea and vomiting in previously diagnosed migraine



Child 12–17 years: 3–6 mg twice daily, tablets to be placed high between upper lip and gum and left to dissolve


Adult: 3–6 mg twice daily, tablets to be placed high between upper lip and gum and left to dissolve

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