MIANSERIN HYDROCHLORIDE

Indications & Dose:

Depressive illness (particularly where sedation is required)

• BY MOUTH

Adult: Initially 30–40 mg daily in divided doses, alternatively initially 30–40 mg once daily, dose to be taken at bedtime, increase dose gradually as necessary; usual dose 30–90 mg

Elderly: Initially 30 mg daily in divided doses, alternatively initially 30 mg once daily, dose to be taken at bedtime, increase dose gradually as necessary; usual dose 30–90 mg 

Contraindications:

Acute porphyrias arrhythmias . during the manic phase of bipolar disorder . heart block . 

Side Effects:

Cautions:

Precautions:

Suicidal patients, convulsive disorders, prostatic hypertrophy, psychiatric disease, severe depression, increased intraacular pressure, narrow-angle glaucoma, urinary retention, cardiac disease (2nd or 3rd degree heart block or sick sinus syndrome, hepatic disease/renal disease, hyperthyroidism, electroshock therapy, elective surgery, elderly, abrupt discontinuation 

Interaction:

Warnings:

Adverse Effects:

Lactations:

Excreted into breast milk; effect on nursing infant unknown but may be of concern 

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anxiety, confusion (especially in elderly), dizziness, drowsiness, extra-pyramidal symptoms (elderly), fatigue, headache, increased psychiatric symptoms, insomnia, memory impairment, nervousness, nightmares, panic, stimulation, tremors, weakness

CV: Dysrhythmias, hypertension, orthostatic hypotension, palpitations, syncope, tachycardia

EENT: Blurred vision, mydriasis, nasal congestion, ophthalmoplegia, tinnitus

GI: Constipation, cramps, diarrhea, dry mouth,epigastric distress, hepatitis, increased appetite, jaundice, nausea, paralytic ileus, stomatitis, vomiting, weight gain

GU: Urinary retention

HEME: Agranulocytosis, easinophilia, leukopenia, thrombocytopenia

SKIN: Photosensitivity, pruritus, rash, sweating, urticaria 

Patient And Carer Advice: