Indications & Dose:
Adjunctive treatment of focal seizures with or without secondary generalisation
Child 6–11 years: 10 mg/kg once daily (max. per dose 300 mg) on day 1, then 10 mg/kg twice daily (max. per dose 300 mg) on day 2, then 10 mg/kg 3 times a day (max. per dose 300 mg) on day 3; usual dose 25–35 mg/kg daily in 3 divided doses, some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate, daily dose maximum to be given in 3 divided doses; maximum 70 mg/kg per day
Child 12–17 years: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9– 3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day), some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate Adult: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9–3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day)
Monotherapy for focal seizures with or without secondary generalisation
Child 12–17 years: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9– 3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day), some children may not tolerate daily increments; longer intervals (up to weekly) may be more appropriate
Adult: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; usual dose 0.9–3.6 g daily in 3 divided doses (max. per dose 1.6 g 3 times a day)
Peripheral neuropathic pain
Adult: Initially 300 mg once daily on day 1, then 300 mg twice daily on day 2, then 300 mg 3 times a day on day 3, alternatively initially 300 mg 3 times a day on day 1, then increased in steps of 300 mg every 2–3 days in 3 divided doses, adjusted according to response; maximum 3.6 g per day
Migraine prophylaxis
Adult: Initially 300 mg daily, then increased to up to 2.4 g daily in divided doses, adjusted according to response
Contraindications:
Side Effects:
Cautions:
Precautions:
Severe renal dysfunction, age <12 yr, tumorigenic in rats (pancreatic adenomas and carcinomas); significance to humans unknown
PREGNANCY The dose should be monitored carefully during pregnancy and after birth, and adjustments made on a clinical basis.
BREAST FEEDING Present in milk—manufacturer advises use only if potential benefit outweighs risk
Interaction:
Drugs
Antacids: Reduce bioBrands Available with Cost of gabapentin by 20%
Warnings:
Adverse Effects:
Lactations:
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
CNS: Abnormal thinking, amnesia, ataxia (13%), depression, dizziness (17%), dysarthria, fatigue (11%), nervousness, nystagmus (8%), somnolence (19%), tremor (7%)
EENT: Diplopia, rhinitis
GI: Dry mouth, dyspepsia
GU: Impotence
HEME: Leukopenia (1%)
MS: Myalgia, twitching
SKIN: Flushing, pruritus
Patient And Carer Advice:
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