GALANTAMINE HBR

Indications & Dose:

Mild to moderately severe dementia in Alzheimer’s disease

• BY MOUTH

Adult: Initially 4 mg twice daily for 4 weeks, increased to 8 mg twice daily for at least 4 weeks; maintenance 8–12 mg twice daily 

Contraindications:

Hypersensitivity to galantamine hydrobromide or its components, severe hepatic or renal impairment (creatinine clearance less than 9 ml/min/1.73 m2

Side Effects:

Cautions:

Avoid in gastro-intestinal obstruction . avoid in urinary outflow obstruction . avoid whilst recovering from bladder surgery . avoid whilst recovering from gastrointestinal surgery . cardiac disease . chronic obstructive pulmonary disease . congestive heart failure . electrolyte disturbances . history of seizures . history of severe asthma . pulmonary infection . sick sinus syndrome . supraventricular conduction abnormalities . susceptibility to peptic ulcers . unstable angina

Precautions:

Interaction:

DRUGS

amitriptyline, fluoxetine, fluvoxamine, quinidine: Possibly decreased galantamine clearance

anticholinergics: Possibly interference with cholinesterase activity cholinergic agonists, cholinesterase inhibitors, neuromuscular blockers: Possibly exaggerated effects of these drugs and galantamine cimetidine: Possibly increased galantamine bioavailability

ketoconazole, paroxetine: Increased galantamine bioavailability 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Aggression, asthenia, depression, dizziness, fatigue, fever, headache, insomnia, malaise, somnolence, stroke, suicidal ideation, syncope, tremor

CV: AV block, bradycardia, chest pain, MI, myocardial ischemia

EENT: Rhinitis

GI: Abdominal pain, anorexia, diarrhea, flatulence,

GI bleeding, indigestion, nausea, vomiting

GU: Hematuria, incontinence, renal failure or insufficiency, UTI

HEME: Anemia

Other: Dehydration, hypokalemia, weight loss 

Patient And Carer Advice: