TIOTROPIUM BROMIDE

Indications & Dose:

Maintenance treatment of chronic obstructive pulmonary disease

• BY INHALATION

Adult: 18 micrograms once daily

Maintenance treatment of chronic obstructive pulmonary disease

 Adjunct to inhaled corticosteroids and longacting beta2 agonists for the maintenance treatment of patients with asthma who have suffered one or more severe exacerbations in the last year

• AEROSOL CAPSULES

Adults. 18 mcg (1 capsule) with 2 inhalations once daily using Handi Haler inhalation device 

Contraindications:

Hypersensitivity to atropine or its derivatives, including ipratropium, tiotropium, or their components

PREGNANCY Manufacturer advises avoid—limited data available.

BREAST FEEDING Manufacturer advises avoid—no information available.

RENAL IMPAIRMENT Plasma-tiotropium concentration raised. Manufacturer advises use only if potential benefit 

Side Effects:

Cautions:

Precautions:

Interaction:

DRUGS

anticholinergics: Possibly increased anticho-linergic effects 

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Depression, difficulty speaking, dizziness, paresthesia, stroke

CV: Angina, atrial fibrillation, chest pain, hypercholesterolemia, palpitations, peripheral edema, supraventricular tachycardia, tachycardia

EENT: Application site irritation (glossitis, mouth ulceration, pharyngolaryngeal pain), blurred vision, cataract, dry mouth, epistax-is, eye pain, glaucoma, hoarseness, laryngitis, oral candidiasis, pharyngitis, rhinitis, sinusitis, stomatitis, throat irritation, visual halos

ENDO: Hyperglycemia

GI: Abdominal pain, constipation, dyspha-gia, gastroesophageal reflux, indigestion,intestinal obstruction, ileus, vomiting

GU: Urinary difficulty, urine retention, UTI MS: Arthritis, leg or skeletal pain, myalgia

RESP: Cough, paradoxical bronchospasm, upper respiratory tract infection

SKIN: Pruritus, rash, urticaria Other: Allergic reaction, angioedema, candidiasis, flulike symptoms, infection 

Patient And Carer Advice: