PENTOXIFYLLINE (Oxpentifylline)

Indications & Dose:

Peripheral vascular disease | Venous leg ulcer (adjunct)

• BY MOUTH

Adult: 400 mg 2–3 times a day

Contraindications:

 Acute myocardial infarction . cerebral haemorrhage . extensive retinal haemorrhage . severe cardiac arrhythmias 

Side Effects:

Rare Angina . hypotension

Very rare Bleeding

Frequency not known Agitation . diarrhoea . dizziness . flushing . headache . intra-hepatic cholestasis . nausea . sleep disturbances . tachycardia . thrombocytopenia . vomiting

PREGNANCY Manufacturer advises avoid—no information available.

BREAST FEEDING Present in milk—manufacturer advises use only if potential benefit outweighs risk.

HEPATIC IMPAIRMENT Manufacturer advises reduce dose in severe impairment.

RENAL IMPAIRMENT Reduce dose by 30–50% if eGFR less than 30 mL/minute/1.73m2.

Cautions:

Avoid in acute porphyrias p. 930 . coronary artery disease . hypotension

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: