NICORANDIL

Indications & Dose:

Prophylaxis and treatment of stable angina (second-line)

• BY MOUTH 

Adult: Initially 5–10 mg twice daily, then increased if tolerated to 40 mg twice daily; usual dose 10–20 mg twice daily, use lower initial dose regimen if patient susceptible to headache 

Contraindications:

cardiogenic shock; left ventricular failure with low filling pressures; hypotension; breast-feeding.

Side Effects:

headache (especially on initiation, usually trnasitory); cutaneous vasodilation with flushing; nausea, vomiting, dizziness, weakness also reported; rarely oral ulceration, myalgia, and rash; at high dosage, reduction in blood pressure and/or increase in heart rate; angioedema, hepatic dysfunction, and anal ulceration also reported.

Cautions:

Hypovolaaemia; low systolic blood pressure; acute pulmonary oedema; acute myocardial infarction with acute left ventricular failure and low filling pressures; pregnancy

Precautions:

Interaction:

DRIVING: Patients should be warned not to drive or operate machinery until it is established that their performance is unimpaired.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: