IVABRADINE

Indications & Dose:

Treatment of angina in patients in normal sinus rhythm

• BY MOUTH

Adult: Initially 5 mg twice daily for 3–4 weeks, then increased if necessary to 7.5 mg twice daily; reduced if not tolerated to 2.5–5 mg twice daily, heart rate at rest should not be allowed to fall below 50 beats per minute Elderly: Initially 2.5 mg twice daily, heart rate at rest should not be allowed to fall below 50 beats per minute

Mild to severe chronic heart failure

• BY MOUTH

Adult: Initially 5 mg twice daily for 2 weeks, then increased if necessary to 7.5 mg twice daily; reduced if not tolerated to 2.5 mg twice daily, heart rate at rest should not be allowed to fall below 50 beats per minute to severe chronic heart failure

Contraindications:

Ivabradine is contraindicated in sick sinus syndrome, and cannot be used concomitantly with inhibitors of CYP3A4 such as azole antifungals (suc as ketoconazole), macrolide antibiotics, nefazodone and antiretroviral drugs nelfinavir and ritonavir.

Side Effects:

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

luminous phenomena, retina, headaches

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: